I always have problems with the red filaments. I have two different red filaments. For red filaments, I always put on an adhesion skirt around the model. It will take some time for the skirt to print. While printing the skirt, I adjust the Z-axis high until the printout looks OK. If the filament does not stick, I lower the Z-axis or if the printout is too thin I raise the Z-axis. I have a Creality CR-10 Pro V2. If I print from the SD card, after the printing starts, I can go to adjustment and change the Z-axis high with 0.01 mm increment until the skirt prints right. However, if I print from the computer via the USB port from the Cura Slicer, the print adjustment feature will not be available on the printer. I would then first set the printer at Leveling screen where I can adjust the Z-axis at 0.1 mm increment up or down while printing the skirt.

I believe you have used too many settings on the Cura Slicer before you know what and how the settings will affect the printout. I would start with the Recommended setting first. There are very few things you have to do. Then slowly add more settings later.

I bought the same printer as yours. I even bought the bed leveling kit. I have so much trouble with the printer that I tell myself this should not be this hard. I return the printer and bought a Creality SR-10s Pro V2. It comes with automatic bed leveling, a touch screen, and a larger printing volume. My trouble was over. Sure the newer print cost more but well worth the extra money. At least the assemble only take 4 screws for the vertical columns and 2 screws for the spool holder. I can start printing within an hour after opening the box.

I always have problems with the red filaments. I have two different red filaments. For red filaments, I always put on an adhesion skirt around the model. It will take some time for the skirt to print. While printing the skirt, I adjust the Z-axis high until the printout looks OK. If the filament does not stick, I lower the Z-axis or if the printout is too thin I raise the Z-axis. I have a Creality CR-10 Pro V2. If I print from the SD card, after the printing starts, I can go to adjustment and change the Z-axis high with 0.01 mm increment until the skirt prints right. However, if I print from the computer via the USB port from the Cura Slicer, the print adjustment feature will not be available on the printer. I would then first set the printer at Leveling screen where I can adjust the Z-axis at 0.1 mm increment up or down while printing the skirt.

I use the latest Cura Slice 4.10.0 which should be the same as the Creality Slicer. After I load the STL file, You can click on Edit on the top, and then click on Arrange All Models. Your models will be centered.